John Frampton  

John Frampton, PhD

Assistant Professor,
School of Biomedical Engineering,
Dalhousie University

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Tel: (902) 494-4175


Dr. John Frampton is a tissue engineer and Tier 2 Canada Research Chair in Cell, Biomaterial and Matrix Interaction. He is dedicated to pushing the boundaries of biomaterials in the field of neural tissue engineering, for purposes not only of developing experimental models but also for developing revolutionary new materials for clinical use in neural repair and regeneration. Among many grants and awards, Dr. Frampton has received:

  • NSERC funding to explore the assembly of biomaterials in multi-phase liquid systems
  • Canada Foundation for Innovation John R. Evans Leaders Fund equipment and infrastructure support to enable the development of cell-material micro-assemblies for promoting functional integration of soft-tissue constructs
  • A concept award from the Congressionally Directed Medical Research Program to study the programming of cells for allotransplant surveillance
  • Early career investigator award from Cystic Fibrosis Canada to characterize the mechanisms of antibiotic persistence in pseudomonas aeruginosa

Dr. Frampton is working with colleagues, Drs. Jeremy Brown, Rob Adamson, James Fawcett, and Adrienne Weeks, on a $2.68 million Atlantic Innovation Fund (AIF) project to develop a miniature ablation endoscope for guided neurosurgery.

Academic background

John Frampton received a BSc in biology from the State University of New York (SUNY) at Albany, New York, in 2004. He stayed on at SUNY to further his studies in neurobiology, neural engineering and cell-to-cell interactions, receiving a PhD in 2009. Dr. Frampton then moved on to the University of Michigan in Ann Arbor, Michigan, where he spent five years doing post-doc training in tissue engineering, microfluidics and disease models. Upon completion of this training in 2014, he moved to Halifax, Nova Scotia, to take up the position of assistant professor in the School of Biomedical Engineering at Dalhousie University. He has received numerous awards for outstanding scholarship, from organizations including the National Institutes of Health and the Institute of Physics.

 Selected Publications

Mackenzie Ruthven, Kristin Ko, Rishima Agarwal and John Frampton. Microscopic Evaluation of Aqueous Two-Phase System Emulsion Characteristics Enables Rapid Determination of Critical Polymer Concentrations for Solution Micropatterning. Analyst.

G.Y. Liu, R. Agarwal, K.R Ko, M. Ruthven, H.T. Sarhan, J.P. Frampton. (2017). Templated assembly of collagen fibers directs cell growth in 2D and 3D. Biomaterials.

(IF: 2.6) Kristin Ko and John Frampton. (2016). Developments in 3D neural cell culture models – the future of neurotherapeutics testing? Expert Review of Neurotherapeutics. 16(7): 739-741.

(IF: 3.5) Frampton JP, Tsuei M, White JB, Abraham A, Takayama S. (2015). Aqueous two-phase system­mediated antibody micropatterning enables multiplexed immunostaining. Biotechnology Journal. 10(1):121-125.

(IF: 11.8) Frampton JP, Leung BM, Lesher-Perez SC, Bingham EL, Wang JD, Sarhan H, EI-Sayed MEH, Feinberg SE, Takayama S. (2015). Rapid assembly of cells into macroscale tissue constructs at biphasic liquid interfaces. Advanced Functional Materials. 25(11): 1694-1699.

(IF: 5.8) Frampton JP, Lai D, Lounds M, Chung KW, Kim JS, Mansfield JF, Takayama S. (2015). Elongation of fibers from highly viscous dextran solutions enables fabrication of rapidly dissolving drug carrying fabrics. Advanced Healthcare Materials. 4(2): 313-319.

(IF: 5.6) Toshiyuki Takehara, Takeshi Teramura, Yuta Onodera, John Frampton and Kanji Fukuda. (2015). Cdh2 stabilizes FGFR1 and contributes to primed-state pluripotency in mouse epiblast stem cells. Scientific Reports. TBD

(IF: 3.5) John P. Frampton. (2015). Liquid-in-liquid antibody confinement provides new possibilities for multiplexed diagnostics. Expert Review of Molecular Diagnostics. 15(4): 445-447.

***(IF:-S.6) Lai D*, Frampton JP, Tsuei M*, Kao A*, Takayama S. (2014). Label-free direct visual analysis of hydrolytic enzyme activity using aqueous two-phase system droplet phase transitions. Analytical Chemistry. 86(8): 4052-4057.

(IF: Not Determined) Simon AB, Frampton JP, Huang NT, Kurabayashi K, Paczesny S, Takayama S. (2014). Aqueous two-phase systems enable multiplexing of homogeneous immunoassays. Technology.
2(2): 176-184.
(IF: 5.6) Frampton JP, White JB, Simon AB, Tsuei M, Paczesny S, Takayama S. (2014). Aqueous two­phase system patterning of detection antibody solutions for cross-reaction-free multiplex ELISA. Scientific Reports. 4: 1-9.

(IF: 11.8) Frampton JP*, Fan ZZ*, Simon A*, Chen D, Deng CX, Takayama S. (2013). Aqueous two­phase system patterning of microbubbles: localized induction of apoptosis in sonoporated cells. Advanced Functional Materials. 23(27): 3420-3431.

Frampton JP, White JB, Abraham AT, Takayama S. (2013). Cell co-culture patterning using aqueous two-phase systems. Journal of Visualized Experiments. 73: e50304.

(IF: 3.1) Teramura T, Onodera Y, Takehara T, Frampton JP, Matsuoka T, Ito S, Nakagawa K, Miki Y, Hosoi Y, Hamanishi C, Fukuda K. (2013). Mesenchymal stem cells induced in severe hypoxic condition from rabbit embryonic stem cells contribute to articular cartilage regeneration in allograft models. Cell Transplantation. 22(2): 309-329.

(IF::4.4) Baac HY, Frampton JP, Ok JG*, Takayama S, Guo JL. (2013). Localized micro-scale disruption of cells·using laser-generated focused ultrasound. Journal of Biophotonics. 6(11-12): 905-910.

(IF: 5.8) Frampton JP, Shi H, Kao A, Parent JM, Takayama S. (2013). Delivery of proteases in aqueous two-phase systems enables direct purification of stem cell colonies from feeder cell co-cultures for differentiation into functional cardiomyocytes. Advanced Healthcare Materials. 2(11): 1440-1444.

(IF: 4.6) Fang Y*. Frampton JP*, Raghavan S*, Sabahi-Kaviani R*, Luker G, Deng CX, Takayama S. (2012). Rapid generation of multiplexed co-cultures using aqueous two-phase exclusion patterning and acoustic droplet ejection. Tissue Engineering, Part C. 18(9): 647-657.

(IF: Not Reported) Teramura T, Frampton JP. (2012). Induced pluripotent stem cells in reproductive medicine. Reproductive Medicine and Biology. 12(2): 39-46.

Perez SC*, Frampton JP, Takayama S. (2012). Microfluidic systems: a new toolbox for
pluripotent stem cells. Biotechnology Journal. 8(2): 180-191.

(IF: 3.7) Teramura T, Sugimoto H, Frampton JP, Kida Y, Nakano M, Kawakami M, Fukunaga N, Onodera Y, Takehara T, Fukuda K, Hosoi Y. (2012). Generation of rabbit embryonic stem cell-lines from immature rabbit ovarian follicles. Stem Cells and Development. 22(6): 928-938.

(IF: 2.6) Frampton JP, *Guo C, Pierchala BA. (2012). Expression of axonal protein degradation machinery in sympathetic neurons is regulated by nerve growth factor. Journal of Neuroscience Research. 90(8):1533-1546.

Last Updated (Monday, 17 April 2017 20:16)